This iris assessment for thiophanatemethyl consists of hazard identification and doseresponse assessment data and provides support for epa risk management decisions. This inventory summarizes evaluations of pesticides that have been performed by the joint faowho meeting on pesticide residues jmpr. The most recent section 3 risk assessment performed for thiophanatemethyl was the hed. Environmental protection and toxic substances november. Pesticide registration forms these forms are in pdf format and require the. Systemic turf and ornamental fungicide for control of a broad spectrum of diseases of herbaceous, bedding, flowering and tropical foliage plants, shrubs, trees and flowers in the landscape, interiorscape, nursery and greenhouse, containerized woody shrubs and trees, and turfgrass. Us epa, pesticide product label, thiophanate methyl 4. Thiophanate methyl an overview sciencedirect topics.
Epa, based on scientific studies showing that they. For crops without labeled uses of thiophanatemethyl, observe a 30day plantback restriction. For male reproductive toxicity, the supporting study was a chronic rat study nisso 1972a. If you want more options, follow the instructions for category a on an epa chemicalresistance category selection chart.
A gradual or total loss of pest control may occur over time if these fungicides are used repeatedly in the same fields. Pesticide information about thiophanate methyl uc ipm. Epas ecological risk assessment suggests that tm dose not pose a. Thiophanatemethyl technical epa registration number. The amended label referred to above, submitted in connection with registration under the federal insecticide, fungicide and rodenticide act, as amended, is acceptable. Thiophanate methyl is a low acute toxicity chemical. When a pesticide is eligible for reregistration, epa explains the basis for its decision in a reregistration eligibility decision red document. Thiophanate methyl is a member of the class of thioureas that is the dimethyl ester of 1,2phenylenedicarbamothioylbiscarbamic acid. An interim assessment analysis of oncogenic dietary risk on the chemical thiophanate methyl. Since it targets a broad spectrum of diseases and plants, it has been used widely since 1973. Environmental protection agency, unless otherwise indicated.
Facts thiophanate methyl pesticide all pesticides sold or distributed in the united states must be registered by reregistration epa, based on scientific studies showing that they can be used without posing. Thiophanatemethyl tm thiophanatemethyl benzimidazole is a broadspectrum systemic fungicide that is absorbed by the roots and leaves of the treated plants. Thiophanate methyl is a broadspectrum fungicide used on food and feed. This iris summary has been removed from the iris database and. If after using thiophanate methyl 85 wdg as directed and the treatment is not effective, a tolerant or resistant strain of fungi may be present. Both this supplemental label and the full thiophanate methyl 4. United states prevention, pesticides october 2005 environmental protection and toxic substances agency 7508c pesticide reregistration use profile r. If after using topsin m wsb as recommended, and the treatment is not effective, a tolerant or resistant strain of fungi may be present. In assessing the potential for additional sensitivity of infants and children to residues of thiophanate methyl and mbc, epa considered data from developmental toxicity studies in the rat and rabbit and a 2generation reproduction study in the rat. If you want more options, follow the instructions for category c on an epa chemicalresistance selection chart. Facts thiophanate methyl all pesticides sold or distributed in the united states must be registered by epa, based on scientific studies showing that they can be used without posing. Epa announced in a 2004 federal register notice that chemicals.
Active ingredient frac brand name of fungicide active. In october 2005 the us epa published a red for thiophanatemethyl and its main metabolite carbendazim. Teratology study in rabbits with thiophanate methyl epa reg. Prenatal and postnatal sensitivity of thiophanate methyl. The fungicide methyl thiophanate widely used to control some of the most. This action is in response to epa s granting of emergency exemptions under section 18 of the federal insecticide. This regulation establishes timelimited tolerances for residues of thiophanate methyl and its metabolite methyl 2 benzimidazoyl carbamate mbc in or on citrus and blueberry. Pesticide registration forms these forms are in pdf format and require the acrobat. Agricultural manual of requirements and guidelines. Agencys revised risk assessments for thiophanatemethyl, epa has identified risk. Us epa, pesticide product label, thiophanatemethyl 50%. Thiophanatemethyl is a fungicide used on tree, vine, and root crops references. Us epa pesticides fact sheet for thiophanatemethyl. Tm is applied on the majority of crop by postemergent broadcast.
Manual manipulation of individual algal cells across with agar surface with a. An analysis of current thiophanate methyl uses, their benefits, the role of alternatives, impacts to agriculture from changes in thiophanate methyl use patterns, and applicator exposure 12 introduction 12 ornamentals 12 turfgrass diseases controlled by thiophanate methyl 14 dollar spot 14 brown patch 18. Thiophanate methyl has structural similarities to propylthiouracil, a known inducer of thyroid tumors in rats and mice. Specimen label thiophanatemethyl 85%wdg revised date. To ensure proper receipt by epa, your objections and hearing requests must. Thiophanatemethyl tm thiophanatemethyl fungicide label. Do not use products containing thiabendazole as substitutes for thiophanate methyl 85 wdg, as they are of. Human health assessment information on a chemical substance is included in the iris database. Thiophanate methyl may be applied as a dip treatment for rose budwood, nursery stock and cut flowers, or for potato pieces and peanuts as a seed treatment. Thiophanatemethyl per gallon keep out of reach of children caution see inside booklet for additional precautionary statements.
Us epa pesticides reregistration eligibility decision red for. Pesticide residues in food food and agriculture organization of the. Program and regulatory information about this substance, including links to epa applicationssystems, statuesregulations, or other sources that track or regulate this substance. If after using thiophanate methyl 85 wdg as recommended and the treatment is not effective, a tolerant or resistant strain of fungi may be present. Nufarm thiophanatemethyl group 1 fungicide tmethyl 4. Do not use products containing f 1 thiabendazole or other products containing thiophanate wi. Environmental protection and toxic substances november 2004 agency 7508c r. Index to pesticide chemical names, part 180 tolerance information, and food and feed commodities by commodity december 12, 2012. Environmental protection agency national center for environmental assessment. Tm is a systemic fungicide used on a variety of tree, vine, and root crops. This fact sheet summarizes the information in the red document for reregistration case 2680, thiophanatemethyl tm and its primary metabolite carbendazim methyl 2 benzimidazole carbamate or mbc. Biochemical aspects thiophanatemethyl is rapidly and almost completely absorbed 8889% after oral administration of a dose of 14 mgkg bw.
These indexes are current as of the date indicated in the pdf file. Chemical and physical properties thiophanatemethyl is the accepted common name for the fungicide dimethyl 1,2phenylenebisiminocarbonothioyl bisicarbamate. Thiophanate methyl is incompatible with strong acids and bases, and with strong reducing agents such as hydrides. As long as these precautions are followed, thiophanate methyl 4. It was determined that the acute and chronic dietary.
Standard for the uniform scheduling of drugs and poisons. Any fungal population may contain individuals naturally resistant to this product and other group 1 fungicides. All pesticides sold or distributed in the united states must be registered by. Specimen label thiophanate methyl 85%wdg revised date. This iris summary has been removed from the iris database and is available for historical reference purposes. These indexes are current as of the date indicated on this pdf. Additional acute toxicity testing with channel catfish is being required because the chemically related compounds thiophanate methyl and benomyl are highly toxic to the ictalurid catfish family. This iris assessment for thiophanate methyl consists of hazard identification and doseresponse assessment data and provides support for epa risk management decisions. Us epa pesticides index to pesticide types and families.
Incompatible with strong oxidizing acids, peroxides. Based on the developmental and reproductive data on thiophanatemethyl and mbc, epa determined that an additional 3x safety factor for thiophanatemethyl and that an additional 10x safety factor for mbc for the protection of infants and children as required by fqpa should be retained. It is used as a broadspectrum systemic fungicide for agricultural use in australia. The listing of thiophanatemethyl was based upon three studies u. No later than one 1 day after the detained bags of thiophanate methyl technical and their contents if appropriate have been relabeled with the epa accepted label. Thiophanate methyl is a fungicide used on tree, vine, and root crops references.
It does not include the maximum residue levels mrls that have been recommended by jmpr. Thiophanate methyl is rated high in hazard because it is classified as a likely human carcinogen and some of the potential exposures to children following lawn applications exceed the epa s level of concern. Discontinue the use of thiophanate methyl 85 wdg for at least one season. Thiophanatemethyl fungicide doityourself pest control. Hold eye open and rinse slowly and gently with water for 1520 minutes. Thiophanate ethyl has extremely low toxicity to birds and moderate toxicity to fish and aquatic invertebrates. Details of the supplier of the safety data sheet manufacturer address. The reconsideration of the active constituent thiophanatemethyl, registration of. Pesticide tolerance information is updated in the code of federal regulations on a weekly basis. Thiophanatemethyl is low in water solubility and is not expected to bind. The listing of thiophanate methyl was based upon three studies u. Thiophanatemethyl is rapidly excreted approximately 47% in urine and approximately 40% in bile within 48 hours of administration.
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